Essentially, G.I. Joe: Sigma 6 is a continuation of the two direct-to-video G.I. Joe CGI movies, G.I. Joe: Spy Troops and G.I. Joe: Valor vs. Venom, both films produced by Reel FX Studios. Several references are made to events from Valor vs. Venom, such as Cobra Commander being captured and in prison, Overkill recovering from his injuries, and General Hawk suffering a change in his DNA. Snake Eyes continues to have Kamakura and Jinx as his apprentices.