Richard, a husband and father living with brain cancer, drives his wheelchair into a pool at a family BBQ. Everyone but his son think that it was suicide from the pain but House will stop at nothing to figure out his true ailment.

House is affected by the fact that he thinks he didn't solve the last case while a young boy, who believes aliens tortured him, is brought in.

House and his team face a lot of moral dilemmas when a patient wants them to help him end his life.

A ten-year-old boy begins screaming in pain, but nobody knows why, because he is autistic and cannot explain. House refuses to use his office because it has new carpet.

A husband and wife being treated cause Foreman to ponder the strength of true love, and House abuses one too many patients with potentially devastating repercussions.

An obese man in a coma presents treatment challenges, but finding out what's wrong with him may be the most challenging test of all. Elsewhere, Tritter ramps up his vendetta against House.

When the son of a man in a vegetative state starts going into a coma, the vegetative man is reawakened chemically by House, who hopes to get some clues to the son's problems.

A young man collapses at his job, and House makes a game of establishing the diagnosis until things turn critical, and Tritter increases the pressure on Wilson.

While a little girl's life and limbs are in jeopardy, Tritter becomes more manipulative and House suffers withdrawal.

Wilson presents the deal to House and then convinces Cuddy to back him up, meanwhile the team is flummoxed by a patient's condition and various members keep seeking out House for his opinion even though he may not be prepared to assist.

House checks himself into rehab just before his trial, but a different game entirely may be afoot. Elsewhere, the team attempts to treat a firefighter who can't stop shivering.

House returns to the hospital after a short stint in rehab; Cuddy comes to collect on the debt of perjuring herself for House; House encounters a patient who tests positive for an STI and says she was raped recently.

A young man is stricken during sex with his girlfriend, and House must determine why his organs are suddenly shutting down. Finding the cause is like looking for a needle in a haystack.

On Valentine's Day, House meddles in relationships as he works to diagnose a teenager who has a genetic inability to feel pain.

House struggles to find out why a pianist savant is losing his ability to play. Ultimately, a decision must be made as to how much brain is necessary for a normal quality of life.

A patient whose relative has called in a favor with Cuddy presents with nonspecific minor symptoms that turn life-threatening, but House is distracted by a dream and an inability to urinate.

When a pregnant woman has a stroke, the team is at a loss after all tests reveal nothing, but when her organs start shutting down Cuddy takes over the case.

House and Cuddy are flying back to the US from an international conference in Singapore. While en route a mysterious disease strikes one passenger and an epidemic unfolds, causing House to diagnose in midair since they have missed the halfway mark by passing the north pole. Back in Princeton, Wilson and House's lackeys have a confusing case of what is ailing a woman w...

A young girl is ailed with diseases that usually strike people much older than her 6 years of age. But before House can diagnose her, her brother starts exhibiting the same symptoms she was admitted with. During all of this House gives Wilson tickets that a patient had given to him for a play. Ensuing a discussion on why men take women to plays. Wilson decides to take...

The cause of a woman's TIA stumps the team, and Foreman's family visits.

Wilson is preparing his 14-year-old patient, Nick, for a bone marrow transplant when the donor, Nick's younger brother Matty, suddenly starts sneezing. Since Nick's immune system has been destroyed by the chemotherapy for his cancer, he cannot risk a marrow donation from Matty while Matty is ill. House decides that the fastest way to find out what's wrong with Matty i...

A college girl suddenly coughs up blood during karate class. Foreman resigns. A vegan couple has problems with floating poop. House secretly drugs Wilson with amphetamine.

When a teenage chess player assaults his opponent, the team struggles to determine whether the problem is organic or psychological. Clinic Cases: Spotted sunburn.

A couple risk their lives getting from Cuba to see House, but his preoccupation with staff issues may cost the woman her life.