The Crusades. The battles that take place every 200 or so years between the Goddess Athena and Hades, the Lord of the Underworld. In an 18th century European country town, just as the Crusade is dawning, live Tenma and Alone. They have completely different personalities but are the best of friends. One day, Alone meets a woman named Pandora. From that day, the cogs of...

At the Sanctuary, Tenma begins his training and meets Yato. Tenma manages to find Sasha, Alone's younger sister. Sasha is attacked by Worm Raimi, until Shion Aries vanquishes him. Tenma then learns that Sasha is the reincarnation of Athena. Two years later, Tenma becomes the Pegasus Saint after winning his rank rightfully in a combat. Back in Italy, Alone is suffering...

Three Silver Saints are revived by Hades to kill Sasha, but are defeated by Dohko and Shion. As a self punishment for killing their comrades, Dohko and Shion go to Tenma's hometown in Italy where Specters, Hades' soldiers, have been located. Upon realizing that each of his friends have been killed, Tenma finds Alone who destroys a painting of Tenma which causes his de...

Another Bronze Saint lost in the previous fight, Unicorn Yato, finds Tenma's dead body and is guided by a woman named Yuzuriha to an area known as Jamir. There, Yuzuriha's master reveals that Tenma can be revived if his soul is brought from the Underworld as his body is preserved by Sasha's Cosmos infused Leash of Flowers. Yato and Yuzuriha go to the Underworld where ...

Griffin Minos, one of three Hades' three most powerful Specters known as "Judges", and his men arrive at the Sanctuary and kill of several Athena Saints. Their march toward the Sanctuary is stopped by a field of red roses, which kills several Specters as they try to cross. The Pisces Gold Saint, Albafica makes his presence known before the invading Specters and easily...

Albafica tells Minos that his men will perish, and as they reach the outskirts of the village they are killed off by a bloody rose trap. Minos finds this amusing and applauds the Pisces Saint for living up the image of a Gold Saint. Albafica temporarily breaks free but to no avail, and is recaptured by Minos who then proceeds to snap the life out of Albafica. Minos go...

Yuzuriha reveals to Tenma and Yato that their real mission is to pick the fruits of the legendary Sapindus tree that grows in the underworld. On their way, they are found by Hell's Watchdog Cerberus and Alone, who tries to lure the Pegasus Saint into his army and then reveals his plans to invade the Sanctuary. As the last and most unexpected obstacle, Tenma is challen...

Picking 108 fruits of the Sapindus tree, Tenma, Yato and Yuzuriha start their way back to the world of the living. Meanwhile, Specters head towards Jamir and find themselves caught in Virgo Asmita's trap. Returning to life, Tenma, Yato and Yuzuriha are reunited with Hakurei, who explains the true purpose behind the fruits of the Sapindus tree: they will be able to sea...

Minos' Specters, previously killed by Pisces Albafica's Bloody Rose trap, are brought back to life. Now, they find themselves face to face with Taurus Aldebaran, who proves to be capable of dealing with them with his arms crossed. While Aldebaran and Dohko patrol the Sanctuary's vicinity, Bennu Kagaho arrives, seeking revenge against the Libra Saint - however, he meet...

The fight between Aldebaran and Kagaho reaches its climax. Bennu recalls old memories with the arrival of the Taurus Saint's disciples, and decides to take on his opponent with full power; on the other hand, Aldebaran decides to unleash his most powerful technique in order to end the battle. During the night, peace is shaken: Alone himself invades the Sanctuary and wr...

Tenma returns before Sasha and Alone and the three childhood friends are reunited at last. Alone unleashes his guard dog Cerberus on Tenma and Sasha, but they evade the three headed dog. Tenma defeats Cerberus, but is rendered useless when trying to strike Alone. Pope Sage shows himself having surrounded Hades with hundreds of talismans he inherited from the previous ...

Hypnos and Thanatos confront Pandora on how she let Hades out of her sight. Having concerns whether it is Hades or Alone that is running the show, Pandora feels that Tenma must die in order for Hades to truly be in control. Pandora sends two assassins: Bat Wimber and Dullhan Cube. Wimber's bats put everyone in the Sanctuary to sleep. As the two Specters are about to k...

Guilty over Taurus Albebaran's sacrifice, Tenma tries to leave the Sanctuary and face Alone by himself. He is intercepted by Cancer Manigoldo and is incarcerated on Sage's orders as he is valuable in the fight against Hades. Hakurei returns to the Sanctuary and convinces his brother Sage to let Tenma go. Yato and Yuzuriha break him out of his imprisonment and accompan...