An urban city runs on a special energy resources, known as the "Enetron," but Vaglass, an existence that threatens the life of humanity by stealing the energy. Ryuji Iwasaki aka Blue Buster and Yoko Usami aka Yellow Buster were on a mission to watch out for any suspicious activities. They spotted a suspicious man in a building trying to absorb "Enetron". Both Ryuji and Yoko jumps into action and transform into, "Go-Busters!"