Cursed (2005)

Ellie has been taking care of her younger brother Jimmy since their parents death. One night after picking him up from a party they are involved in a car accident on Mullholland Drive. While trying to rescue a woman from the other car a creature attacks and kills her, also injuring both Ellie and Jimmy. After some research Jimmy realizes the creature could only have been a werewolf. (imdb)
Cast and Information
Directed By: Wes Craven
Written By: Kevin Williamson
Starring: Judy Greer, Christina Ricci, Jesse Eisenberg, Milo Ventimiglia, Joshua Jackson, Shannon Elizabeth, Michael Rosenbaum, Michelle Krusiec, Portia de Rossi, Wilmer Calderon, Kristina Anapau, Mya
Genres: Comedy, Suspense/Thriller, Horror